Journal: World Journal of Hepatology
Article Title: Ultrasound imaging in orthotopic hepatocellular carcinoma models: Promise, practicality, and points for refinement
doi: 10.4254/wjh.v17.i12.115551
Figure Lengend Snippet: Representative high-frequency ultrasound–based monitoring of orthotopic hepatocellular carcinoma established using the rat hepatoma cell line (N1S1). Tumor volume measurements obtained by ultrasound demonstrate an excellent correlation with reference histological and volumetric assessments ( r = 0.998, P < 0.001; Devan et al ), underscoring the accuracy, reproducibility, and experimental utility of this imaging approach for preclinical tumor evaluation. CT: Computed tomography; HCC: Hepatocellular carcinoma; 3D: Three dimensional; 3R: Replacement, reduction, and refinement. Created in BioRender ( www.biorender.com ).
Article Snippet: A syngeneic orthotopic HCC model was established in male Sprague Dawley rats by subcapsular implantation of the rat hepatoma cell line (N1S1) hepatoma cells into the left lateral liver lobe.
Techniques: Imaging, Computed Tomography